138 calls and 2.33K puts traded on Nov 4, 2026, 2.46K contracts in total. Open interest was 14.36K contracts. Over the past 30 days, volume averaged 1.17K contracts per day. The DNLI option volume chart shows volume by strike and expiration date.

Denali Therapeutics IV rank is 33, so its 30-day implied volatility of 89.4% is in the lower part of its one-year range. Over the past year it ranged from 28.6% on Dec 23, 2025 to 210.1% on Jan 16, 2026. See the DNLI implied volatility history for a longer view.

The Denali Therapeutics put/call volume ratio was 16.86 on Nov 4, 2026, so puts outnumber calls. The put/call open interest ratio was 1.62. The DNLI open interest chart shows calls and puts at each strike.

As of the Nov 4, 2026 close, max pain for Denali Therapeutics options about one week from expiration was $17.18, 18.0% below the $20.95 close. The DNLI max pain chart shows it for every expiration date.

Based on 7-day implied volatility of 108.9%, options price a move of about ±$3.16 (±15.1%) over the next week, a range of roughly $17.79 to $24.11 from the Nov 4, 2026 close. The DNLI expected move chart shows it for every expiration date.