Option activity is usually called unusual when a contract trades much more volume than its open interest, which can mean traders are opening new positions.

On Nov 4, 2026, Exelixis options traded 600 contracts against 49.11K open, a volume to open interest ratio of 0.01, well below its 20-day average. The table above lists the contracts with the highest ratios.

Calls made up 69.3% of Exelixis option volume on Nov 4, 2026, a put/call ratio of 0.44, so calls outnumber puts. The EXEL option volume chart shows calls and puts by strike.

Exelixis Inc is a biopharmaceutical firm that discovers, develops, and commercializes treatments for cancer.