418 calls and 2.18K puts traded on Nov 4, 2026, 2.6K contracts in total. Open interest was 52.68K contracts. Over the past 30 days, volume averaged 1.55K contracts per day. The IONS option volume chart shows volume by strike and expiration date.

Ionis Pharmaceuticals IV rank is 21, so its 30-day implied volatility of 61.0% is in the lower part of its one-year range. Over the past year it ranged from 28.5% on May 7, 2026 to 180.5% on Jan 16, 2026. See the IONS implied volatility history for a longer view.

The Ionis Pharmaceuticals put/call volume ratio was 5.21 on Nov 4, 2026, so puts outnumber calls. The put/call open interest ratio was 0.59. The IONS open interest chart shows calls and puts at each strike.

As of the Nov 4, 2026 close, max pain for Ionis Pharmaceuticals options about one week from expiration was $44.86, 11.8% above the $40.14 close. The IONS max pain chart shows it for every expiration date.

Based on 7-day implied volatility of 67.9%, options price a move of about ±$3.78 (±9.4%) over the next week, a range of roughly $36.36 to $43.92 from the Nov 4, 2026 close. The IONS expected move chart shows it for every expiration date.