2.44K calls and 154 puts traded on Nov 4, 2026, 2.59K contracts in total. Open interest was 45.74K contracts. Over the past 30 days, volume averaged 3.9K contracts per day. The PRME option volume chart shows volume by strike and expiration date.

Prime Medicine IV rank is 31, so its 30-day implied volatility of 116.4% is in the lower part of its one-year range. Over the past year it ranged from 44.6% on May 18, 2026 to 278.7% on Jul 17, 2026. See the PRME implied volatility history for a longer view.

The Prime Medicine put/call volume ratio was 0.06 on Nov 4, 2026, so calls outnumber puts. The put/call open interest ratio was 0.26. The PRME open interest chart shows calls and puts at each strike.

As of the Nov 4, 2026 close, max pain for Prime Medicine options about one week from expiration was $4.03, 18.7% below the $4.96 close. The PRME max pain chart shows it for every expiration date.

Based on 7-day implied volatility of 117.6%, options price a move of about ±$0.81 (±16.3%) over the next week, a range of roughly $4.15 to $5.77 from the Nov 4, 2026 close. The PRME expected move chart shows it for every expiration date.