1.27K calls and 280 puts traded on Nov 4, 2026, 1.55K contracts in total. Open interest was 14.06K contracts. Over the past 30 days, volume averaged 559 contracts per day. The MDGL option volume chart shows volume by strike and expiration date.

Madrigal Pharmaceuticals IV rank is 17, so its 30-day implied volatility of 64.2% is near the bottom of its one-year range. Over the past year it ranged from 37.7% on May 6, 2026 to 194.0% on Oct 16, 2026. See the MDGL implied volatility history for a longer view.

The Madrigal Pharmaceuticals put/call volume ratio was 0.22 on Nov 4, 2026, so calls outnumber puts. The put/call open interest ratio was 0.46. The MDGL open interest chart shows calls and puts at each strike.

As of the Nov 4, 2026 close, max pain for Madrigal Pharmaceuticals options about one week from expiration was $470.46, 17.4% above the $400.68 close. The MDGL max pain chart shows it for every expiration date.

Based on 7-day implied volatility of 68.9%, options price a move of about ±$38.21 (±9.5%) over the next week, a range of roughly $362.47 to $438.89 from the Nov 4, 2026 close. The MDGL expected move chart shows it for every expiration date.